O37: SYSTEMATIC REVIEW AND PROPORTIONAL META-ANALYSIS OF SURVIVAL FOLLOWING NEOADJUVANT CHEMORADIATION AND LIVER TRANSPLANTATION IN UNRESECTABLE HILAR CHOLANGIOCARCINOMA

Abstract Introduction Despite improvements in survival for other tumour types, the prognosis of hilar cholangiocarcinoma (CC) continues to be extremely poor. Since publication Mayo protocol 2000, an increasing number case series around world have reported excellent outcomes after neoadjuvant chemoradiation followed by liver transplantation (NCR-LT) unresectable CC. Method MEDLINE, EMBASE, Scopus and Web Science databases were searched data extracted from relevant studies. A proportional meta-analysis was conducted pool 1, 3- 5-year disease recurrence rates following NCR-LT. Result Twenty studies comprising 428 patients eligible final analysis. The pooled overall LT without therapy 71.2% (95% CI 62.2 - 79.4), 48.0% 35.0 60.9) 31.6% 23.1 40.7). These improved 82.8% 73.0 90.8), 65.5% 48.7 80.5) 65.1% 55.1 74.5) administration a protocol. rate 51.7% 33.8 69.4) who did not undergo treatment 24.1% 17.9 30.9) those did. Conclusion In CC, NCR-LT confers long-term selected able complete transplantation. Patients with primary sclerosing cholangitis most favourable outcomes. high is concern when considering extending national graft allocation schemes. CC Cholangiocarcinoma, Neoadjuvant Chemoradiation & Liver Transplantation Take-home message patients, results greater than 50%. concomitant post-transplantation.